Development of sequence assembly methods for large plants genome
Assembling a highly contiguous and accurate reference genome sequence is a prerequisite for genetic and functional studies at the whole-genome level. As sequence technologies evolve, researchers can select from a plethora of methods to assemble the best genome sequence possible. The computational project (targeted at students of computer science, bioinformatics or related disciplines) aims at extending, simplifying and benchmarking an existing prototypic pipeline for genome sequence assembly and applying it to real datasets for large plant genomes. See: Mascher et al. A chromosome conformation capture ordered sequence of the barley genome. Nature 2017.ve-cell CRISPR imaging in plants reveals dynamic telomere movements. Plant J 91, 565-573.
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