07.06.2019 05:01 Alter: 2 yrs

Development of CRISPR-based methods suitable for life imaging of chromosomes

Elucidating how the genome is spatio-temporally organised inside the nucleus is imperative to understand the regulation of genes and non-coding sequences during development. Emerging techniques of chromatin imaging promise to bridge the long-standing gap between sequencing studies disclosing genomic information and imaging studies providing spatial and temporal information. The project aims to harness the CRISPR-Cas9 system to develop a pioneering tool to visualize defined genomic loci in living cells of eudicot and monocot plants. see: Dreissig et al (2017). Live-cell CRISPR imaging in plants reveals dynamic telomere movements. Plant J 91, 565-573.

Please visit our website for more information on the work of [link]our group.

If you are interested in this topic, please contact [link]Prof. Dr. Andreas Houben for further information.