Die Bildung von Samen stellt eine bemerkenswerte Innovation dar, die die evolutionäre Leistungsfähigkeit von Pflanzen beeinflusst. Getreide ist für die menschliche Ernährung, für die Tierfütterung und die industrielle Verarbeitung unverzichtbar geworden. Der gegenwärtige Klimawandel und die damit verbundene Zunahme von extremen Wetterereignissen stellen zusätzliche Herausforderungen für die landwirtschaftliche Praxis und Produktivität dar.

Unser allgemeines Ziel ist es, die molekularen Kontrollmechanismen der Samenbildung auf Zell-, Gewebe- und Organebene zu verstehen und neue Ansätze zur Verbesserung des Samenertrags und der Samenqualität bei Getreidearten zu etablieren, insbesondere bei Gerste und Weizen, aber auch bei anderen Kulturpflanzen wie Reis, Raps, Zuckerrüben und Sorghum.

Ein besonderer Fokus ist die Identifizierung von genregulatorischen Netzwerken durch die Untersuchung von Transkriptionsregulatoren, Signaltransduktionswege von Pflanzenhormonen und reaktiven Sauerstoffspezies (ROS) sowie der Nährstofftransport während der Kornfüllung. Langfristiges Ziel unserer Arbeit ist es, das Ertragspotenzial und die Qualität von Pflanzensamen unter aktuellen und zukünftigen Klimabedingungen zu verbessern oder zu stabilisieren.

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Alternation of generations and embryogenesis

The conquest of the land by plants is one of the most remarkable transitions of life on earth that altered the atmosphere and paved the way for the evolution of complex animals. Land plants (embryophytes) most likely evolved from charophycean freshwater green algae around 450 million years ago. Terrestrialization required major adaptations, including the development of mechanical support for the plant body, adaptation to a gaseous and relative dry environment, the formation of novel organs for the acquisition of water and nutrients, the ability to cope with novel abiotic and biotic stresses but also a reprogramming of the reproduction through the evolution of embryogenesis. In the frame of MAdLand DFG priority programme 2237 we study the role of ROS scavenging and producing enzymes in the mosses Marchantia polymorpha and Physcomitrium patens, which can both reproduce asexual and sexual, and thereby represent unique organisms for studying genes essential for embryogenesis.

In addition, we study selected transcription factors (TFs) that show embryo-developmental stage specific expression patterns in Arabidopsis. Based upon the gene regulatory networks (GRNs) that these thus far uncharacterised TFs control we can assign a biological function for them and specifically analyse their role during embryogenesis. Furthermore, our group is part of the BMBF funded AVATARS project and focusses on rapeseed embryogenesis during beneficial and detrimental conditions. Within this project, gene expression analysis of dissected rapeseed embryos will be performed and used for the modelling of gene regulatory networks

TCS signal transduction and regulatory mechanisms of tissue differentiation in cereal grains

Developing cereal grains are complex structures consisting of maternal and filial tissues. Sequences of cell proliferation, differentiation, maturation and disintegration occur in the different grain tissues in a coordinated manner. Since a long time, we are studying tissue-specific processes in cereal and legume seeds, and established laser capture microdissection (LCM)-based RNA-seq analysis for cereals (Brandt et al., 2018) and other species. Tissue-specific RNA-seq of developing barley endosperm transfer cells (ETCs) identified the Two-Component Signaling (TCS) system as essential signal transduction pathway for early endosperm specification and differentiation. Current functional genomics studies focus on the role of selected TCS elements on barley endosperm and grain development. Histidine kinase 1 (HvHK1) was identified as a receptor component with a unique expression in the syncytial endosperm domain at the maternal-filial boundary. Knock-down of HvHK1 by RNAi impairs transfer cell specification in the central ETC region, abolishes cell wall ingrowths and produces smaller grains with reduced starch accumulation (Hertig et al., 2020). RNA-seq of the altered cell type confirmed loss of transfer cell identity and gene regulatory network modelling predicted main regulatory links governing cellularization of ETCs. New models for modification of further TCS genes with potential functions in grain (and also spike) development have been established using the CRISPR/Cas9-technology in frame of a DFG project. Phenotypes of mutated plants will be characterised by genetic and histological analysis of the progenies (ongoing work). In addition, downstream transcription factors of the TCS pathways are functionally characterised.

Elucidation of gene regulatory networks in cereals using DAP-seq

Both the response of a plant to its environment and how plant organs grow to characteristic sizes and shapes is genetically controlled. Intriguingly, the cause behind improved plant traits is often due to altered gene regulatory networks. Transcription factors are key determinants in regulating growth and adaptation responses by modulating the activity of tens to hundreds of genes. In contrast to Arabidopsis thaliana, we virtually have no idea on the gene networks controlled by transcription factors in crops. Recently, we managed to setup DNA-affinity purification and sequencing (DAP-seq) in barley through an IPK-funded Flagship project. This technique allows us to yield insight into the biology and binding site architecture of numerous barley TFs. In addition, we use tissue-specific libraries to study the binding profiles of the selected TFs in their natural context. Currently we are optimizing the method for wheat and in the near future plant to adapt it for Sorghum bicolor.

Based upon the identified networks we select promising candidate TFs with a putative role in grain filling for functional analysis. Currently, several NAC and AP2/ERF transcription factors have been selected for which transgenic models will be established to validate our approach.

Regulation of cell proliferation, differentiation and signalling by reactive oxygen species

Reactive oxygen species (ROS) are inevitable byproducts of several metabolic processes or cascade of oxidation-reduction reactions that take place in aerobic organisms. Initially mainly recognised for their potential to induce damage to cells, it has become clear that plants actively produce and scavenge ROS to modulate cellular processes and trigger a ROS burst for stress signalling. Interestingly, in the apical regions of plants a ROS gradient between superoxide and hydrogen peroxide is observed, in which the first is linked to stemness and the second to differentiation.

Recently we uncovered a family of myb-like transcription factors that modulate cell expansion in plants. These KUODA (Chinese for enlarge) TFs are plant specific and conserved in all plant species, suggesting that they have a universal role in plants. Currently we investigate their role in sugar beet in collaboration with KWS. In addition, we are highly interested in other TFs that specifically regulate ROS-related genes during development and stress. In addition, we study ROS signalling during the initial phase of salt stress in rice in collaboration with the Plant Biotechnology group of the University of Bielefeld. Salt stress in rice provokes a ROS burst that triggers the activity of several transcriptional cascades. Currently we mainly focus on the SERF1 cascade and the branching of the ROS signal.

Role of protein stability during development

Wear and tear on proteins due to the environment in which they act and the biochemical processes they control, can result in misfolding, aggregation, or mistargeting. Therefore, cells monitor the state of each protein through either chaperones or components of diverse proteolytic pathways. Still, the largest fraction of the proteins that are removed through proteostasis systems are actually undamaged. Based on the demand for specific proteins during cellular processes, unwanted proteins are removed. For instance, during cell proliferation and cell differentiation, which are sequential processes that involve specific protein sets during the course of development. In addition, many proteins have a short half-life, which potentially minimises the risk of protein damage to prevent the accumulation of aberrant and damaging proteins. Protein turnover is performed mostly through the ubiquitin–proteasome system (UPS) and autophagy. Here we study the transcriptional regulation of the proteasome during development. In addition, we characterise labile transcription factors with a role in plant development and a need for ROS gradients.



Barley HISTIDINE KINASE1 (HvHK1) coordinates endosperm transfer cell (ETC) specification in the young endosperm required for efficient grain filling. Gene regulatory network modeling predicted distinct phosphorelay and hormone signalling modules as main regulatory links that are directed by HvHK1.


Gerste HISTIDINE KINASE1 (HvHK1) koordiniert die Spezifikation der Endosperm-Transferzellen (ETC) im jungen Endosperm, die für eine effiziente Kornfüllung erforderlich sind. Mit Hilfe der Modellierung genregulatorischer Netzwerke konnten verschiedene Phosphorelisierungs- und Hormon-Signalwege als wichtigste regulatorische Verbindungen von HvHK1 vorhergesagt werden.

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Wissenschaftliches Personal
Frohn, Stephanie
Nagesh, Keerthana
Nihalani, Vibha
Reiss, Erik
Wang, Haojie
Technisches Personal
Blaschek, Katrin
Vasquez Valerio, Fransisco Antonio
Weichert, Heiko
Ziplys, Anne

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Mora-Ramirez I, Weichert H, von Wirén N, Frohberg C, de Bodt S, Schmidt R-C, Weber H:

The da1 mutation in wheat increases grain size under ambient and elevated CO2 but not grain yield due to trade-off between grain size and grain number. Plant-Environ. Interact. 2 (2021) 61-73. https://doi.org/10.1002/pei3.10041

Pronin D, Börner A, Weber H, Scherf K A:

WHEATSCAN – Did breeding from 1890 until today change the immunoreactivity of wheat? In: Vereinigung der Pflanzenzüchter und Saatgutkaufleute Österreichs (Ed.): Breeding for resilience against biotic and abiotic stresses, 71. Tagung, 23. -24. November 2020, Online Conference. (Series: Tagung / Vereinigung der Pflanzenzüchter und Saatgutkaufleute Österreichs, Vol. 71) Tulln an der Donau: Universität für Bodenkultur Wien, Department für Nutzpflanzenwissenschaften (2021) ISBN 978-3-900932-81-7, 13-14.

Reis R S, Deforges J, Schmidt R R, Schippers J H M, Poirier Y:

An antisense noncoding RNA enhances translation via localised structural rearrangements of its cognate mRNA. Plant Cell 33 (2021) 1381–1397. https://dx.doi.org/10.1093/plcell/koab010

Sasidharan R, Schippers J H M, Schmidt R R:

Redox and low-oxygen stress: signal integration and interplay. Plant Physiol. 186 (2021) 66–78. https://dx.doi.org/10.1093/plphys/kiaa081

Thiel J, Koppolu R, Trautewig C, Hertig C, Kale S M, Erbe S, Mascher M, Himmelbach A, Rutten T, Esteban E, Pasha A, Kumlehn J, Provart N J, Vanderauwera S, Frohberg C, Schnurbusch T:

Transcriptional landscapes of floral meristems in barley. Sci. Adv. 7 (2021) eabf0832. https://dx.doi.org/10.1126/sciadv.abf0832

Tran N:

Repression activity of KUODA transcription factors and their interactions with TOPLESS/TOPLESS-RELATED co-repressors in Arabidopsis thaliana. (Bachelor Thesis) Nijmegen, The Netherlands, Han University of Applied Sciences (2021) 54 pp.

Watkins J M, Ross-Elliott T J, Shan X, Lou F, Dreyer B, Tunc-Ozdemir M, Jia H, Yang J, Oliveira C C, Wu L, Trusov Y, Schwochert T D, Krysan P, Jones A M:

Differential regulation of G protein signaling in Arabidopsis through two distinct pathways that internalize AtRGS1. Sci. Signal. 14 (2021) eabe4090. https://dx.doi.org/10.1126/scisignal.abe4090


Boudichevskaia A, Ruban A, Thiel J, Fiebig A, Houben A:

Tissue-specific transcriptome analysis reveals candidate genes associated with the process of programmed chromosome limination in Aegilops speltoides. Int. J. Mol. Sci. 21 (2020) 7596. https://doi.org/10.3390/ijms21207596

Foyer C H, Baker A, Wright M, Sparkes I A, Mhamdi A, Schippers J H M, Van Breusegem F:

On the move: redox-dependent protein relocation in plants. J. Exp. Bot. 71 (2020) 620-631. https://dx.doi.org/10.1093/jxb/erz330

Hertig C, Melzer M, Rutten T, Erbe S, Hensel G, Kumlehn J, Weschke W, Weber H, Thiel J:

Barley HISTIDINE KINASE 1 (HvHK1) coordinates transfer cell specification in the young endosperm. Plant J. 103 (2020) 1869-1884. https://dx.doi.org/10.1111/tpj.14875

Pronin D, Börner A, Weber H, Scherf K A:

Wheat (Triticum aestivum L.) breeding from 1891 to 2010 contributed to increasing yield and glutenin contents but decreasing protein and gliadin contents. J. Agric. Food Chem. 68 (2020) 13247-13256. https://dx.doi.org/10.1021/acs.jafc.0c02815

Steiner E, Israeli A, Gupta R, Shwartz I, Nir I, Leibman-Markus M, Tal L, Farber M, Amsalem Z, Ori N, Müller B, Bar M:

Characterization of the cytokinin sensor TCSv2 in arabidopsis and tomato. Plant Methods 16 (2020) 152. https://dx.doi.org/10.1186/s13007-020-00694-2


Dreyer B H, Schippers J H M:

Copper-Zinc superoxide dismutases in plants: evolution, enzymatic properties, and beyond. In: Roberts J A (Ed.): Annual Plant Reviews online. : John Wiley & Sons (2019) 1-36. https://dx.doi.org/10.1002/9781119312994.apr0705

Hajheidari M, Wang Y, Bhatia N, Vuolo F, Franco-Zorrilla J M, Karady M, Mentink R A, Wu A, Oluwatobi B R, Müller B, Dello Ioio R, Laurent S, Ljung K, Huijser P, Gan X, Tsiantis M:

Autoregulation of RCO by low-affinity binding modulates cytokinin action and shapes leaf diversity. Curr. Biol. 29 (2019) 4183-4192. https://dx.doi.org/10.1016/j.cub.2019.10.040

Neuser J, Metzen C C, Dreyer B H, Feulner C, van Dongen J T, Schmidt R R, Schippers J H M:

HBI1 mediates the trade-off between growth and immunity through its impact on apoplastic ROS homeostasis. Cell Rep. 28 (2019) 1670-1678.e1673. https://dx.doi.org/10.1016/j.celrep.2019.07.029

Radchuk V, Sharma R, Potokina E, Radchuk R, Weier D, Munz E, Schreiber M, Mascher M, Stein N, Wicker T, Kilian B, Borisjuk L:

The highly divergent Jekyll genes, required for sexual reproduction, are lineage specific for the related grass tribes Triticeae and Bromeae. Plant J. 98 (2019) 961-974. https://dx.doi.org/10.1111/tpj.14363

Takenaka S, Weschke W, Brückner B, Murata M, Endo T R:

Chromosome arm locations of barley sucrose transporter gene in transgenic winter wheat lines. Front. Plant Sci. 10 (2019) 548. https://dx.doi.org/10.3389/fpls.2019.00548

Wagner S, Steinbeck J, Fuchs P, Lichtenauer S, Elsässer M, Schippers J H M, Nietzel T, Ruberti C, Van Aken O, Meyer A J, Van Dongen J T, Schmidt R R, Schwarzländer M:

Multiparametric real-time sensing of cytosolic physiology links hypoxia responses to mitochondrial electron transport. New Phytol. 224 (2019) 1668-1684. https://dx.doi.org/10.1111/nph.16093

Wang H, Schippers J H M:

The role and regulation of autophagy and the proteasome during aging and senescence in plants. Genes 10 (2019) 267. https://dx.doi.org/10.3390/genes10040267

Yang Y, Kloos S, Mora-Ramírez I, Romeis J, Brunner S, Li Y, Meissle M:

Transgenic winter wheat expressing the sucrose transporter HvSUT1 from barley does not affect aphid performance. Insects 10 (2019) 388. https://dx.doi.org/10.3390/insects10110388


Brandt R, Mascher M, Thiel J:

Laser-capture microdissection-based RNA-seq of barley grain tissues. In: Murray G I (Ed.): Laser Capture Microdissection: Methods and Protocols. (Series: Methods in molecular biology, Vol. 1723) New York, NY: Humana Press (2018) ISBN 978-1-4939-7557-0, 397-409. https://doi.org/10.1007/978-1-4939-7558-7_23

Philipp N, Weichert H, Bohra U, Weschke W, Schulthess A W, Weber H:

Grain number and grain yield distribution along the spike remain stable despite breeding for high yield in winter wheat. PLoS One 13 (2018) e0205452. https://dx.doi.org/10.1371/journal.pone.0205452

Radchuk V, Tran V, Radchuk R, Diaz-Mendoza M, Weier D, Fuchs J, Riewe D, Hensel G, Kumlehn J, Munz E, Heinzel N, Rolletschek H, Martinez M, Borisjuk L:

Vacuolar processing enzyme 4 contributes to maternal control of grain size in barley by executing programmed cell death in the pericarp. New Phytol. 218 (2018) 1127-1142. https://dx.doi.org/10.1111/nph.14729


Abebaw Y M:

Ectopic expression of a Vicia faba amino acid permease (VfAAP1) improves grain yield and stimulates seedling root growth in wheat (Triticum aestivum). (PhD Thesis) Halle/S., Martin-Luther-Universität Halle-Wittenberg, Naturwissenschaftliche Fakultät I Biowissenschaften (2017) 127 pp.

Radchuk V, Riewe D, Peukert M, Matros A, Strickert M, Radchuk R, Weier D, Steinbiß H-H, Sreenivasulu N, Weschke W, Weber H:

Down-regulated sucrose transporters HvSUT1, HvSUT2 affects sucrose homeostasis along its delivery path in barley grains. J. Exp. Bot. 68 (2017) 4595-4612. https://doi.org/10.1093/jxb/erx266

Tran Thi Thuy V:

The role of vacuolar processing enzymes in programmed cell death in maternal tissues of the developing barley grain. (PhD Thesis) Halle/S., Martin-Luther-Universität Halle-Wittenberg, Naturwissenschaftliche Fakultät I Biowissenschaften (2017) 106 pp.

Weichert H, Högy P, Mora-Ramirez I, Fuchs J, Eggert K, Koehler P, Weschke W, Fangmeier A, Weber H:

Grain yield and quality responses of wheat expressing a barley sucrose transporter to combined climate change factors. J. Exp. Bot. 68 (2017) 5511-5525. https://dx.doi.org/10.1093/jxb/erx366


Ammann M K:

Analyse der Ertragsparameter und molekularen Grundlagen der RNAi-vermittelten Suppression der ABA-8’Hydroxylase-Aktivität in Gerste. (Bachelor Thesis) Jena, Friedrich-Schiller-Universität Jena, Biologisch-Pharmazeutische Fakultät, Institut für Ernährungswissenschaften (2016) 46 pp.

Bohra U:

Phenotypic variation of the trait grain yield distribution along the spike in a winter wheat population of elite lines and genetic resources. (Master Thesis) München, Technische Universität München, Biotechnologie gartenbaulicher Kulturen Weihenstephan, Department Pflanzenwissenschaften (2016) 43 pp.

Cápal P, Endo T R, Vrána J, Kubaláková M, Karafiátová M, Komínková E, Mora-Ramírez I, Weschke W, Doležel J:

The utility of flow sorting to identify chromosomes carrying a single copy transgene in wheat. Plant Methods 12 (2016) 24. https://dx.doi.org/10.1186/s13007-016-0124-8

Hertig C:

Characterization and interaction studies of two-component signaling components expressed in barley endosperm transfer cells. (Master Thesis) Halle/S., Martin-Luther-Universität Halle-Wittenberg, Naturwissenschaftliche Fakultät I, Institut für Biologie (2016) 72 pp.

Kaspar-Schoenefeld S, Merx K, Jozefowicz A M, Hartmann A, Seiffert U, Weschke W, Matros A, Mock H-P:

Label-free proteome profiling reveals developmental-dependent patterns in young barley grains. J. Proteomics 143 (2016) 106-121. https://dx.doi.org/10.1016/j.jprot.2016.04.007

Mora Ramirez M I:

Transgenic winter wheat – increased sucrose uptake capacity accelerates plant development and enhances grain yield. (PhD Thesis) Halle/S., Martin-Luther-Universität Halle-Wittenberg, Naturwissenschaftliche Fakultät I Biowissenschaften (2016) 89 pp.

Peukert M, Thiel J, Mock H-P, Marko D, Weschke W, Matros A:

Spatiotemporal dynamics of oligofructan metabolism and suggested functions in developing cereal grains. Front. Plant Sci. 6 (2016) 1245. https://dx.doi.org/10.3389/fpls.2015.01245

Staroske N, Conrad U, Kumlehn J, Hensel G, Radchuk R, Erban A, Kopka J, Weschke W, Weber H:

Increasing abscisic acid levels by immunomodulation in barley grains induces precocious maturation without changing grain composition. J. Exp. Bot. 67 (2016) 2675-2687. https://dx.doi.org/10.1093/jxb/erw102


Kohl S:

N remobilisation during barley grain filling and the influence of sink-strength alteration in developing wheat grains. (PhD Thesis, kumulativ) Halle/S., Martin-Luther-Universität Halle-Wittenberg, Naturwissenschaftliche Fakultät I Biowissenschaften (2015) 115 pp.

Kohl S, Hollmann J, Erban A, Kopka J, Riewe D, Weschke W, Weber H:

Metabolic and transcriptional transitions in barley glumes reveal a role as transitory resource buffers during endosperm filling. J. Exp. Bot. 66 (2015) 1397-1411. https://dx.doi.org/10.1093/jxb/eru492

Pielot R, Kohl S, Manz B, Rutten T, Weier D, Tarkowská D, Rolčík J, Strnad M, Volke F, Weber H, Weschke W:

Hormone-mediated growth dynamics of the barley pericarp as revealed by magnetic resonance imaging and transcript profiling. J. Exp. Bot. 66 (2015) 6927–6943. https://dx.doi.org/10.1093/jxb/erv397

Wobus U:

Das Institut Gatersleben 1943-1990: Eine außeruniversitäre Forschungseinrichtung zwischen Selbstbestimmung und politischer Lenkung. In: Pasternack P (Ed.): Ein Vierteljahrhundert später. Zur politischen Geschichte der DDR-Wissenschaft. (Series: Die Hochschule: Journal für Wissenschaft und Bildung, Vol. 24) Lutherstadt Wittenberg: Institut für Hochschulforschung Wittenberg (2015) ISBN 978-3-937573-48-9, 78-88.

Zhang H M, Wheeler S, Xia X, Radchuk R, Weber H, Offler C E, Patrick J W:

Differential transcriptional networks associated with key phases of ingrowth wall construction in trans-differentiating epidermal transfer cells of Vicia faba cotyledons. BMC Plant Biol. 15 (2015) 103. https://dx.doi.org/10.1186/s12870-015-0486-5


Bau D:

Einfluss von ambientem und erhöhtem CO2 auf Phänotyp und Inhaltsstoffe von Winterweizenkörnern: vergleichende Analysen von transgener Hochertrags-Linie HOSUT und nicht-transgener basislinien Certo. (Bachelor Thesis) Halle/S., Martin-Luther-Universität Halle-Wittenberg, Naturwissenschaftliche Fakultät I Biowissenschaften, Institut für Biologie (2014) 30 pp.

Gubatz S, Weschke W:

Barley grain: development and structure. In: Shewry P R, Ullrich S (Eds.): Barley: chemistry and technology, 2nd ed. St. Paul, Minnesota: AACC International Inc. (2014) ISBN 978-1-891127-79-3, 11-54.

Olsen O-A, Weschke W:

Genetic and molecular aspects of barley grain development. In: Shewry P R, Ullrich S (Eds.): Barley: chemistry and technology, 2nd ed. St. Paul, Minnesota: AACC International Inc. (2014) ISBN 978-1-891127-79-3, 55-70.

Peukert M, Thiel J, Peshev D, Weschke W, Van den Ende W, Mock H-P, Matros A:

Spatio-temporal dynamics of fructan metabolism in developing barley grains. Plant Cell 26 (2014) 3728-3744. https://dx.doi.org/10.1105/tpc.114.130211

Radchuk V, Pirko Y V, Isayenkov S V, Yemets A I, Blume Y B:

cDNA library construction from meristematic tissue of finger millet panicle. Cytol. Genet. 48 (2014) 273-278. https://dx.doi.org/10.3103/S0095452714050089

Saalbach I, Mora-Ramírez I, Weichert N, Andersch F, Guild G, Wieser H, Koehler P, Stangoulis J, Kumlehn J, Weschke W, Weber H:

Increased grain yield and micronutrient concentration in transgenic winter wheat by ectopic expression of a barley sucrose transporter. J. Cereal Sci. 60 (2014) 75-81. https://dx.doi.org/10.1016/j.jcs.2014.01.017

Seiler C, Harshavardhan V T, Reddy P S, Hensel G, Kumlehn J, Eschen-Lippold L, Rajesh K, Korzun V, Wobus U, Lee J, Selvaraj G, Sreenivasulu N:

Abscisic acid flux alterations result in differential ABA signalling responses and impact assimilation efficiency in barley under terminal drought stress. Plant Physiol. 164 (2014) 1677-1696. https://dx.doi.org/10.1104/pp.113.229062

Thiel J:

Development of endosperm transfer cells in barley. Front. Plant Sci. 5 (2014) 108. https://dx.doi.org/10.3389/fpls.2014.00108

Tran V, Weier D, Radchuk R, Thiel J, Radchuk V:

Caspase-like activities accompany programmed cell death events in developing barley grains. PLoS One 9 (2014) e109426. https://dx.doi.org/10.1371/journal.pone.0109426

Weier D, Thiel J, Kohl S, Tarkowska D, Strnad M, Schaarschmidt S, Weschke W, Weber H, Hause B:

Gibberellin-to-abscisic acid balances govern development and differentiation of the nucellar projection of barley grains. J. Exp. Bot. 65 (2014) 5291-5304. https://dx.doi.org/10.1093/jxb/eru289

Weschke W, Weber H:

Grain development. In: Kumlehn J, Stein N (Eds.): Biotechnological approaches to barley improvement. (Series: Biotechnology in agriculture and forestry, Vol. 69) Berlin: Springer (2014) ISBN 978-3-662-44405-4, 139-159. https://dx.doi.org/10.1007/978-3-662-44406-1_8


Hertig C:

Interaktionsstudien von Elementen des Zwei-Komponenten Signalsystems (TCS) aus Gerste mittels Fluoreszenzkomplementation (BiFC). (Bachelor Thesis) Halle/S., Martin-Luther-Universität Halle-Wittenberg, Naturwissenschaftliche Fakultät I Biowissenschaften, Institut für Biologie (2013) 41 pp.

Solbach D:

Characterization and expression of novel SWEET-like sucrose transporters in developing seeds of Arabidopsis and Pisum sativum. (Bachelor Thesis) Halle/S., Martin-Luther-Universität Halle-Wittenberg, Naturwissenschaftliche Fakultät I Biowissenschaften, Institut für Biologie (2013) 46 pp.

Sreenivasulu N, Wobus U:

Seed-development programs: a systems biology-based comparison between dicots and monocots. Annu. Rev. Plant Biol. 64 (2013) 189-217. https://dx.doi.org/10.1146/annurev-arplant-050312-120215

Wu B, Andersch F, Weschke W, Weber H, Becker J S:

Diverse accumulation and distribution of nutrient elements in developing wheat grain studied by laser ablation inductively coupled plasma mass spectrometry imaging. Metallomics 5 (2013) 1276-1284. https://dx.doi.org/10.1039/c3mt00071k

Zietz M:

Exploring the function of X8 domain-containing proteins using co-expression and protein-protein interaction studies. (Bachelor Thesis) Halle/S., Martin-Luther-Universität Halle-Wittenberg, Naturwissenschaftliche Fakultät I Biowissenschaften (2013) 42 pp.


Faix B, Radchuk V, Nerlich A, Hümmer C, Radchuk R, Emery R J, Keller H, Götz K P, Weschke W, Geigenberger P, Weber H:

Barley grains, deficient in cytosolic small subunit of ADP-glucose pyrophosphorylase, reveal coordinate adjustment of C:N metabolism mediated by an overlapping metabolic-hormonal control. Plant J. 69 (2012) 1077-1093. https://dx.doi.org/10.1111/j.1365-313X.2011.04857.x

Kohl S, Hollmann J, Blattner F R, Radchuk V, Andersch F, Steuernagel B, Schmutzer T, Scholz U, Krupinska K, Weber H, Weschke W:

A putative role for amino acid permeases in sink-source communication of barley tissues uncovered by RNA-seq. BMC Plant Biol. 12 (2012) 154. https://dx.doi.org/10.1186/1471-2229-12-154

Pfeiffer H, Weichert H, Klose G, Heremans K:

Hydration behaviour of POPC/C-12-Bet mixtures investigated by sorption gravimetry, P-31 NMR spectroscopy and X-ray diffraction. Chem. Phys. Lipids 165 (2012) 244-251. https://dx.doi.org/10.1016/j.chemphyslip.2012.01.004

Pudelski B, Schock A, Hoth S, Radchuk R, Weber H, Hofmann J, Sonnewald U, Soll J, Philippar K:

The plastid outer envelope protein OEP16 affects metabolic fluxes during ABA-controlled seed development and germination. J. Exp. Bot. 63 (2012) 1919-1936. https://dx.doi.org/10.1093/jxb/err375

Radchuk V, Kumlehn J, Rutten T, Sreenivasulu N, Radchuk R, Rolletschek H, Herrfurth C, Feussner I, Borisjuk L:

Fertility in barley flowers depends on Jekyll functions in male and female sporophytes. New Phytol. 194 (2012) 142-157. https://dx.doi.org/10.1111/j.1469-8137.2011.04032.x

Radchuk V, Radchuk R, Pirko Y, Vankova R, Gaudinova A, Korkhovoy V, Yemets A, Weber H, Weschke W, Blume Y B:

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Deciphering the regulatory mechanisms of abiotic stress tolerance in plants by genomic approaches. Gene 388 (2007) 1-13. https://dx.doi.org/10.1016/j.gene.2006.10.009

Stark M, Manz B, Ehlers A, Küppers M, Riemann I, Volke F, Siebert U, Weschke W, König K:

Multiparametric high-resolution imaging of barley embryos by multiphoton microscopy and magnetic resonance micro-imaging. Microsc. Res. Techniq. 70 (2007) 426-432. https://dx.doi.org/10.1002/Jemt.20426

Stark M, Manz B, Riemann I, Volke F, Weschke W, König K:

Multiphoton and magnetic resonance imaging of barley embryos: comparing micro-imaging techniques across scale and parameter barriers. In: Periasamy A (Ed.): Multiphoton microscopy in the biomedical sciences VII: 21 - 23 January 2007, San Jose, California, USA, proceedings. (Series: Proceedings of SPIE, the International Society for Optical Engineering, Vol. 6442) Bellingham, Wash.: SPIE (2007) ISBN 978-0-8194-6555-9, 644227. https://dx.doi.org/10.1117/12.702364

Strickert M, Sreenivasulu N, Usadel B, Seiffert U:

Correlation-maximizing surrogate gene space for visual mining of gene expression patterns in developing barley endosperm tissue. BMC Bioinformatics 8 (2007) 165. https://dx.doi.org/10.1186/1471-2105-8-165

Weigelt K, Kuster H, Götz K P, Saalbach I, Weber H:

Manipulation of seed metabolism in transgenic pea plants to increase protein content. Journal für Verbraucherschutz und Lebensmittelsicherheit 2 (2007) 107.

Weschke W, Mock H-P, Pietsch C, Radchuk V, Röder M S, Schreiber F, Seiffert U, Sreenivasulu N, Strickert M, Witzel K, Wobus U:

Genetical Genomics der Gerstenkornentwicklung - von der Genexpression zu landwirtschaftlich bedeutsamen Merkmalen. GenomXPress 1 (2007) 12-16.

Wobus U, Mock H-P, Pietsch C, Radchuk V, Röder M, Schreiber F, Seiffert U, Sreenivasulu N, Strickert M, Weschke W, Witzel K:

GABI-SEED: Genetische Grundlagen komplexer agronomischer Merkmale im Getreidekorn entschlüsseln. GenomXPress Sonderausgabe März (2007) 19.


Brüß C, Bollenbeck F, Schleif F-M, Weschke W, Villmann T, Seiffert U:

Fuzzy image segmentation with fuzzy lebelled neural gas. In: Verleysen M (Ed.): Advances in computational intelligence and learning: 14th European Symposium on Artificial Neural Networks, ESANN 2006, Bruges, Belgium, April 26 - 27 - 28, 2006, proceedings. Evere, Belgium: d-side (2006) ISBN 2-930307-06-4, 563-568.

Endler A, Meyer S, Schelbert S, Schneider T, Weschke W, Peters S W, Keller F, Baginsky S, Martinoia E, Schmidt U G:

Identification of a vacuolar sucrose transporter in barley and Arabidopsis mesophyll cells by a tonoplast proteomic approach. Plant Physiol. 141 (2006) 196-207. https://dx.doi.org/10.1104/pp.106.079533

Jogeswar G, Pallela R, Jakka N M, Reddy P S, Rao J V, Sreenivasulu N, Kishor P B K:

Antioxidative response in different sorghum species under short-term salinity stress. Acta Physiol. Plant. 28 (2006) 465-475. https://dx.doi.org/10.1007/BF02706630

Lopato S, Borisjuk L, Milligan A S, Shirley N, Bazanova N, Langridge P:

Systematic identification of factors involved in post-transcriptional processes in wheat grain. Plant Mol. Biol. 62 (2006) 637-653. https://dx.doi.org/10.1007/s11103-006-9046-6

Radchuk R, Radchuk V, Weschke W, Borisjuk L, Weber H:

Repressing the expression of the SUCROSE NONFERMENTING-1-RELATED PROTEIN KINASE gene in pea embryo causes pleiotropic defects of maturation similar to an abscisic acid-insensitive phenotype. Plant Physiol. 140 (2006) 263-278. https://dx.doi.org/10.1104/pp.105.071167

Radchuk V, Borisjuk L, Radchuk R, Steinbiss H H, Rolletschek H, Broeders S, Wobus U:

Jekyll encodes a novel protein involved in the sexual reproduction of barley. Plant Cell 18 (2006) 1652-1666. https://dx.doi.org/10.1105/tpc.106.041335

Röder M S, Kaiser C, Weschke W:

Molecular mapping of the shrunken endosperm genes seg8 and sex1 in barley (Hordeum vulgare L.). Genome 49 (2006) 1209-1214. https://dx.doi.org/10.1139/g06-093

Sreenivasulu N, Radchuk V, Strickert M, Miersch O, Weschke W, Wobus U:

Gene expression patterns reveal tissue-specific signaling networks controlling programmed cell death and ABA- regulated maturation in developing barley seeds. Plant J. 47 (2006) 310-327. https://dx.doi.org/10.1111/j.1365-313X.2006.02789.x

Strickert M, Seiffert U, Sreenivasulu N, Weschke W, Villmann T, Hammer B:

Generalized relevance LVQ (GRLVQ) with correlation measures for gene expression analysis. Neurocomputing 69 (2006) 651-659. https://dx.doi.org/10.1016/j.neucom.2005.12.004

Strickert M, Sreenivasulu N, Peterek S, Weschke W, Mock H-P, Seiffert U:

Unsupervised feature selection for biomarker identification in chromatography and gene expression data. In: Schwenker F, Marinai S (Eds.): Artificial neural networks in pattern recognition: second IAPR Workshop, ANNPR 2006, Ulm Germany, August 31 - September 2, 2006. proceedings. (Series: Lecture Notes in Computer Science, Vol. 4087) Berlin [u.a.]: Springer (2006) ISBN 978-3-540-37951-5, 274-285. https://dx.doi.org/10.1007/11829898_25

Strickert M, Sreenivasulu N, Seiffert U:

Sanger-driven MDSLocalize - a comparative study for genomic data. In: Verleysen M (Ed.): Advances in computational intelligence and learning: 14th European Symposium on Artificial Neural Networks, ESANN 2006, Bruges, Belgium, April 26 - 28, 2006, proceedings. Evere, Belgium: d-side (2006) ISBN 2-930307-06-4, 265-270.

Usadel B, Nagel A, Steinhauser D, Gibon Y, Blasing O E, Redestig H, Sreenivasulu N, Krall L, Hannah M A, Poree F, Fernie A R, Stitt M:

PageMan: an interactive ontology tool to generate, display, and annotate overview graphs for profiling experiments. BMC Bioinformatics 7 (2006) 535. https://dx.doi.org/10.1186/1471-2105-7-535

Wobus U, Sreenivasulu N:

Genomics approaches for the improvement of cereals. In: Freitag J (Ed.): Plant genomics and bioinformatics expression micro arrays and beyond: a course book (European Training and Networking Activity). Potsdam-Golm: MPI-MPP (2006) ISBN 3-00-018316-7, 146-155.

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